在治疗过程中，其不良反应主要表现为急性光毒性反应。可出现轻度红斑、水肿、水疱、脱屑，以及轻度瘙痒、疼痛、暂时性色素沉着等反应，一般患者可耐受，对症处理后可逐渐消退[63]。此外，周俊等[69]研究发现，以常规治疗剂量308nm MEL对小鼠皮肤进行长期照射具有一定致癌性。但人与小鼠种属不同，且小鼠皮肤薄，黑素细胞缺乏，患皮肤癌的风险高于人类。由于该研究对象非人类皮肤，因此此结论尚不能直接评估 308 nm 准分子光对人体皮肤的致癌性，这还需进一步研究。

与脉冲式发光的308nm 准分子激光相比，308nmMEL 是封闭灯管中的稳定308nm 波长的光源[62]，由灯管直接照射，照射光斑面积大，能量无损耗。308 nm 准分子激光因需更换氯罐，耗材成本高，而308 nm MEL 无耗材，因此维护成本和治疗费用相对较低，患者依从性好。这些优势将使 308 nm MEL 在实际应用中更具潜力[63]。

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